1.
Circulation
; 142(2): 184-186, 2020 07 14.
Article
in English
| MEDLINE | ID: covidwho-1394302
Subject(s)
Coronavirus Infections/diagnosis , Pneumonia, Viral/diagnosis , Pulmonary Embolism/diagnosis , Adult , Aged , Aged, 80 and over , Betacoronavirus/isolation & purification , COVID-19 , Coronavirus Infections/complications , Female , Fibrinolytic Agents/therapeutic use , Humans , Intensive Care Units , Length of Stay , Male , Middle Aged , Pandemics , Pneumonia, Viral/complications , Prevalence , Prognosis , Pulmonary Embolism/complications , Pulmonary Embolism/drug therapy , Pulmonary Embolism/epidemiology , Risk Factors , SARS-CoV-2 , Tertiary Care Centers
2.
Am J Gastroenterol
; 115(10): 1716-1718, 2020 10.
Article
in English
| MEDLINE | ID: covidwho-732652
ABSTRACT
INTRODUCTION: We investigated the potential hepatotoxicity of lopinavir/ritonavir recently used in the treatment of Severe Acute Respiratory Syndrome Coronavirus. METHODS: This is a retrospective cohort of critical patients in a teaching hospital: 12 treated with lopinavir/ritonavir and 30 in the standard-of-care group. RESULTS: Elevation occurred more frequently in patients treated with lopinavir/ritonavir (33% vs 6.7%). DISCUSSION: Caution is advised regarding the use of lopinavir/ritonavir in the most severe cases of Severe Acute Respiratory Syndrome Coronavirus.
Subject(s)
Antiviral Agents/adverse effects , Coronavirus Infections/drug therapy , Jaundice/chemically induced , Lopinavir/adverse effects , Pneumonia, Viral/drug therapy , Ritonavir/adverse effects , Aged , Betacoronavirus/isolation & purification , COVID-19 , Coronavirus Infections/complications , Coronavirus Infections/diagnosis , Coronavirus Infections/virology , Dose-Response Relationship, Drug , Drug Administration Schedule , Drug Combinations , Female , Humans , Intensive Care Units/statistics & numerical data , Jaundice/diagnosis , Jaundice/epidemiology , Lopinavir/administration & dosage , Male , Middle Aged , Pandemics , Pneumonia, Viral/diagnosis , Pneumonia, Viral/virology , Prospective Studies , Retrospective Studies , Ritonavir/administration & dosage , SARS-CoV-2 , Severity of Illness Index , Standard of Care/statistics & numerical data , COVID-19 Drug Treatment
3.
Intensive Care Med
; 46(6): 1124-1126, 2020 06.
Article
in English
| MEDLINE | ID: covidwho-108789